Ethamsylate (Aethamzilatum)
ETHAMSYLATE
Synonyms:
Ethamsylate, Aethamzilatum, Dicynene, Dicynone, Etamsylate, Impedil.
Description
Acting substance - Ethamsylate: 2,5-digidroksibenzolsulfonat of diethylamine or 2,5-Dioxibenzolsulfonat diethilammonia salt.
Pharmacological action
The permeability of vascular wall normalizes, it improves microcirculation, hemostatic action renders.
Indications for use
For preventive maintenance and stoppage of hemorrhages with operational interference, injuries, hemorrhagic diatheses, metro and menorrhagia, diabetic angiopathies, in the special cases with the intestinal and pulmonary hemorrhages, is especially shown the application of preparation with the normal indices of the rolling up system of the blood.
Method of application and dose
It is intravenous, is intramuscular, conjunctival, it is retrobulbar and inward. With the preventive purpose the preparation is introduced intravenously or intramuscularly 1 hour prior to operation on 2-4 ml (1-2 ampules) or they give inside 2-3 tablets 3 hours prior to operation. During the operation are if necessary introduced 2-4 ml with the danger of postoperative hemorrhage preventive intravenously introduce 4 8 ml or they give inside 1,5-2 g evenly in the course of twenty-four hours. With the therapeutic purpose in the special cases etamzilat introduce on it is 2nd 4 ml intravenously or intramuscularly, and then through every 4 6 hours on 0.25 g it is parenteral or on 0.5 g inward. With diabetic microangiopathies (retinopathy with the hemorrhages) is assigned etamzilat by courses on 2-3 months, giving on 1 tablet 3 times a day or are introduced intramuscularly on 2 ml (1 ampule) 2 times a day during 10-14 days.
conjunctival retrobulbarly introduce 1 ml of solution.
Side-line action
Heartburn, a feeling of gravity in the epigastric region, hyperemia of face, paresthesia in the lower extremities, a decrease AD, small vertigo, headache.
Contraindications
One ought not to use with the hemorrhages, caused by anticoagulants.
Form of the release
Ampules on 2 ml 12,5%- solution, in the packing of 10 pieces and tablets on 0.25 g, in the packing of 50 pieces.
Storage
List b. In the protected from the light place.
Etamsylate is used for treatment of prevention of thrombosis, venous stasis, varicose veins