Nicotinic acid (Acidum nicotinicum)
the NICOTINIC ACID
Synonyms:
Nicotinic acid, Vitamin B3, Vitamin PP, Acidum nicotinicum, Arelagrin, Induracin, Liplyt, Niacin, Nicodan, Nicodon, Niconacid, Nicotene, Nicovit, Rellagramin, Relonin, Reviton, Vitaplex N
Description
Active substance - nicotinic acid: pyridine-3- carbonaceous acid.
Pharmacological action
Nicotinic acid and amide of nicotinic acid is tightly connected with the coenzymes of codehydrase of the I and codehydrase of the II (NAD and NADP), carrying hydrogen and with those achieving oxidation-reduction functions.
Indications for use
Angiospasm; atherosclerosis (is reduced the content of cholesterol in the blood).
Method of application and dose
Are assigned inward on 0.05 g 2-3 times in a 24 hour period, possibly an increase in the dose to 0.1 g of 2-3 times in a 24 hour period. Parenterally they introduce 1%- ache the solution of sodium of nicotinate on 1 ml of 1 2 times in a 24 hour period during 10-15 days.
Side-line action
Reddening of face and upper half of body with the sensation of tingling and burning, vertigo, the flows of the blood to the head; during the prolonged application of large doses the fatty infiltration of the liver is possible.
Contraindications
Increased sensitivity, stomach ulcer and duodenum (in the stage of aggravation), the expressed disturbances of the function of the liver, gout, hyperuricemia, the severe forms of arterial hypertension and atherosclerosis (intravenous). Limitations to the application: pregnancy, lactation.
Form of the release
Powder, tablet on 0.05 g, in the packing of 50 pieces; in the ampules on 1 ml 1%- solution, in the packing of 10 pieces.
Storage
In the protected from the light, dry, cool place of 3 years.