Peripheral vasodilators and calcium antagonists
This information is not intended for purposes of treatment without physician.
Description of the pharmacological group
Peripheral vasodilators
Medicinal properties
Peripheral vasodilators - these are the preparations, which act predominantly on the most distal divisions of the vascular system (arteriole and venule), which determine the resistance of peripheral vessels and the deposition of the blood in the venous bed in essence.
The number of peripheral vasodilators first of all includes organic nitrates (nitroglycerine, nitrosorbid and other), sodium nitroprusside, molsidomin, prazosin, apressin.
Different preparations act the more or is less selective (or nonselectively) to the capacitive (venous) and resistance (arterial) vessels. Nitrates, nitrites, and also molsidomin more greatly influence the capacitive vessels (venules); sodium nitroprusside - to the resistance vessels (arterioles) and partially to the veins; prazosin and apressin predominantly to the resistance vessels.
They adapt in the complex therapy of heart insufficiency, sharp myocardial infarction, arterial hypertension. Recently was received the wide acceptance of the means, which expand the distal capacitive (venule) and (or) resistance vessels (arterioles). Decreasing the inflow of the blood to the left ventricle, they decrease preliminary and afterload by the myocardium, improve the functional activity of heart, decrease the need of myocardium for oxygen, is decreased pressure in the pulmonary artery.
All peripheral vasodilators must be used under the thorough hemodynamic control with a strict observance of doses. They can strongly lower system AD, cause collaptoid state, worsen blood supply of heart.
On other blockers of calcium channels see “the antagonists of calcium ions”.
Peripheral vasodilators nitroglycerin, nitrosorbid, sodium nitroprusside, molsidomin, minipress (prazosin hydrochloride), apressin used in the treatment of heart failure, acute myocardial infarction, hypertension